Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 14/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.47 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685409 | 0.75 | NISCH (0.66) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL16275243 | 0.75 | NISCH (0.60) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL5476725 | 0.75 | NISCH (0.79) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL6992574 | 0.75 | NISCH (0.72) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL20836837 | 0.73 | NISCH (0.62) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL7011598 | 0.73 | PDCD1LG2 (0.64) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL8973479 | 0.72 | NISCH (0.61) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL3742115 | 0.71 | NISCH (0.56) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL3058419 | 0.71 | NISCH (0.56) | NISCHLMNARECQLTOP2ATOP2B | |
| SCHEMBL2645254 | 0.71 | NISCH (0.58) | NISCHLMNAPDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323570-A | HYPOTENSIVE AGENTS AND TREATING GLAUCOMA | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-04-06 | — | — | US | claimed |
| EP-2738165-B1 | Method by means of phase transfer catalysis | WÖRWAG PHARMA GMBH & CO KG (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-2892895-A1 | MOXONIDINE SYNTHESIS WITH THE AID OF ORGANIC BASES | WÖRWAG PHARMA GmbH & Co. KG (DE) | 2015-07-15 | — | — | EP | disclosed |
| EP-2738165-A1 | Method by means of phase transfer catalysis | WÖRWAG PHARMA GmbH & Co. KG (DE) | 2014-06-04 | — | — | EP | disclosed |
| WO-2014037391-A1 | MOXONIDINE SYNTHESIS WITH THE AID OF ORGANIC BASES | WÖRWAG PHARMA GmbH & Co. KG (DE) | 2014-03-13 | — | — | WO | disclosed |
| EP-1982983-B1 | Improved process for producing moxonidine | CHEMAGIS LTD (IL) | 2011-08-17 | — | — | EP | disclosed |
| US-5914330-A | ADMINISTERING AN IMIDAZOLE-CONTAINING PYRIMIDINE DERIVATIVE EFFECTIVE TO PROTECT AGAINST RENAL FAILURE WITHOUT REDUCING BLOOD PRESSURE | SOLVAY PHARMACEUTICALS GMBH (DE) | 1999-06-22 | — | — | US | disclosed |
| EP-0039037-B1 | PYRIMIDYLTHIO-UREAS, MEDICINES CONTAINING THEM AND THEIR USE | Beiersdorf Aktiengesellschaft (DE) | 1985-01-16 | — | — | EP | disclosed |
| US-4323570-A | HYPOTENSIVE AGENTS AND TREATING GLAUCOMA | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-04-06 | — | — | US | disclosed |
| EP-0039037-A1 | Pyrimidylthio-ureas, medicines containing them and their use | Beiersdorf Aktiengesellschaft (DE) | 1981-11-04 | — | — | EP | disclosed |