Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 15/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.65 |
| ▸ | TSHR | P16473 | 9/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.65 |
| ▸ | USP2 | O75604 | 8/20 | 0.65 |
| ▸ | LMNA | P02545 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.60 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.58 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14529152 | 0.84 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL14529381 | 0.84 | DHFR (0.57) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL13300204 | 0.83 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL2333301 | 0.81 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL1084998 | 0.81 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL13769228 | 0.80 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL18654157 | 0.80 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL938193 | 0.79 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL34467231 | 0.79 | CYP1A2 (0.62) | CYP1A2CYP3A4CYP2D6TSHRHSD17B10 | |
| SCHEMBL12491743 | 0.78 | CYP1A1 (0.56) | CYP1A2TSHRHSD17B10LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324226-B2 | Therapeutic oxy-phenyl-aryl compounds and their use | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-12-04 | — | — | US | disclosed |
| EP-2227460-B1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2012-06-20 | — | — | EP | disclosed |
| US-20110201592-A1 | Therapeutic Oxy-Phenyl-Aryl Compounds and Their Use | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| EP-2227460-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-15 | — | — | EP | disclosed |
| EP-1474147-B1 | PYRIMIDINE-BASED COMPOUNDS USEFUL AS GSK-3 INHIBITORS | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009053694-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
| EP-1318814-B1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201592-A1 | Therapeutic Oxy-Phenyl-Aryl Compounds and Their Use | CHEK2, CHEK1, PLK1 | CYP1A2 1846/4885CYP3A4 3486/4885CYP2D6 2800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.