Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.54 |
| ▸ | OGFRL1 | Q5TC84 | 7/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | VPS4B | O75351 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699747 | 0.86 | OPRM1 (0.58) | OPRM1OGFRL1CYP2C9OPRD1OPRK1 | |
| SCHEMBL698663 | 0.81 | OPRM1 (0.61) | OPRM1OGFRL1CYP2C9OPRD1OPRK1 | |
| SCHEMBL700139 | 0.78 | OPRM1 (0.67) | OPRM1OGFRL1CYP2C9OPRD1OPRK1 | |
| SCHEMBL700959 | 0.77 | OPRM1 (0.61) | OPRM1OGFRL1CYP2C9OPRD1OPRK1 | |
| SCHEMBL699857 | 0.76 | OPRM1 (0.58) | OPRM1OGFRL1CYP2C9HTR2AHTR2B | |
| SCHEMBL699255 | 0.76 | OPRM1 (0.64) | OPRM1OGFRL1CYP2C9OPRD1OPRK1 | |
| SCHEMBL699418 | 0.75 | OPRM1 (0.57) | OPRM1OGFRL1OPRD1OPRK1OPRL1 | |
| SCHEMBL706789 | 0.74 | OPRM1 (0.56) | OPRM1OGFRL1CYP2C9OPRD1OPRK1 | |
| SCHEMBL699256 | 0.72 | OPRM1 (0.62) | OPRM1OGFRL1OPRD1OPRK1OPRL1 | |
| SCHEMBL699742 | 0.71 | OPRM1 (0.55) | OPRM1OGFRL1CYP2C9OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010531-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH ANALGESIC PROPERTIES | GRUENENTHAL GMBH (DE) | 2011-08-17 | — | — | EP | disclosed |