Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511692 | 0.83 | KMT2A (0.49) | KMT2AKEAP1ALDH1A1NQO1MAPK1 | |
| Hydrochloric Acid SCHEMBL23498163 | 0.83 | KEAP1 (0.46) | KMT2AKEAP1ALDH1A1MAPK1ALOX15 | |
| SCHEMBL23653737 | 0.80 | KMT2A (0.44) | KMT2AKEAP1ALDH1A1MAPK1ALOX15 | |
| SCHEMBL21939509 | 0.79 | KMT2A (0.50) | KMT2AALDH1A1MAPK1ALOX15L3MBTL1 | |
| SCHEMBL20562605 | 0.78 | KMT2A (0.56) | KMT2AKEAP1ALDH1A1MAPK1ALOX15 | |
| SCHEMBL10693192 | 0.77 | KMT2A (0.47) | KMT2AKEAP1ALDH1A1MAPK1ALOX15 | |
| SCHEMBL23653466 | 0.77 | KMT2A (0.48) | KMT2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL23498171 | 0.76 | KMT2A (0.42) | KMT2AKEAP1ALDH1A1NQO1MAPK1 | |
| SCHEMBL20505057 | 0.74 | KMT2A (0.53) | KMT2AKEAP1ALDH1A1MAPK1ALOX15 | |
| SCHEMBL29177077 | 0.74 | MEN1 (0.40) | KMT2AKEAP1MAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3625228-B1 | PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-07-07 | — | — | EP | disclosed |