Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | CFD | P00746 | 2/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | GLS | O94925 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21439648 | 0.88 | HDAC1 (0.44) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21439649 | 0.83 | NAMPT (0.40) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21455643 | 0.83 | CFD (0.39) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21455345 | 0.82 | CFD (0.59) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21455907 | 0.82 | SUCNR1 (0.45) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21439709 | 0.81 | SUCNR1 (0.40) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21438957 | 0.81 | CFD (0.44) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21455900 | 0.81 | CFD (0.44) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| SCHEMBL21455634 | 0.80 | CFD (0.60) | NAMPTHDAC1CFDSUCNR1BRD4 | |
| Hexane SCHEMBL21545511 | 0.80 | SUCNR1 (0.39) | NAMPTHDAC1CFDSUCNR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3687506-B1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARM INC (US) | 2021-07-07 | — | — | EP | disclosed |