Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681232 | 0.83 | MAPK1 (0.49) | LRRK2 | |
| SCHEMBL18616272 | 0.81 | JAK3 (0.40) | HDAC1ATRBMPR1BBMPR1AACVRL1 | |
| SCHEMBL18860985 | 0.80 | PDGFRB (0.40) | FYNPDGFRBKDRMAP4K4 | |
| SCHEMBL23616837 | 0.80 | ALOX5AP (0.33) | ATRBMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL21785546 | 0.73 | ATR (0.33) | FYNHDAC1LRRK2ATRBMPR1B | |
| SCHEMBL18861206 | 0.72 | CHEK2 (0.33) | FYNPDGFRBKDRMAP4K4 | |
| SCHEMBL18616300 | 0.71 | CCNA2 (0.39) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18616581 | 0.71 | HRH3 (0.40) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18519532 | 0.70 | MASP2 (0.34) | — | |
| SCHEMBL21467222 | 0.70 | MAPK1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3845527-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | Beijing Yuezhikangtai Biomedicines Co., Ltd. (CN) | 2021-07-07 | — | — | EP | disclosed |