Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | FOS | P01100 | 9/20 | 0.38 |
| ▸ | JUN | P05412 | 9/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 9/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 9/20 | 0.38 |
| ▸ | RELA | Q04206 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24786349 | 0.87 | SYK (0.44) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL31612079 | 0.83 | SYK (0.49) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL23618678 | 0.79 | SYK (0.45) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL24786915 | 0.76 | SYK (0.41) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL23618785 | 0.76 | GSK3A (0.44) | SYKNFKB1MAPTKDM4ENR2F2 | |
| SCHEMBL23625487 | 0.74 | SYK (0.48) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL24786905 | 0.74 | SYK (0.42) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL31465569 | 0.74 | SYK (0.47) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL30479295 | 0.72 | SYK (0.46) | SYKFOSJUNNFKB1NFKB2 | |
| SCHEMBL24852041 | 0.72 | SYK (0.49) | SYKFOSJUNNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136463-A1 | PURINE DERIVATIVE AND MEDICAL USE THEREOF | 成都百裕制药股份有限公司 | 2021-07-08 | — | — | WO | disclosed |