Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.56 |
| ▸ | JAK1 | P23458 | 4/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | TEC | P42680 | 1/20 | 0.56 |
| ▸ | TXK | P42681 | 1/20 | 0.56 |
| ▸ | BLK | P51451 | 1/20 | 0.56 |
| ▸ | BMX | P51813 | 1/20 | 0.56 |
| ▸ | ITK | Q08881 | 1/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24106807 | 0.84 | ADORA1 (0.48) | JAK3JAK1BTKTECTXK | |
| SCHEMBL28855720 | 0.84 | JAK3 (0.59) | JAK3JAK1BTKTECTXK | |
| SCHEMBL23221794 | 0.82 | JAK3 (0.66) | JAK3JAK1BTKTECTXK | |
| SCHEMBL21333438 | 0.82 | JAK3 (0.66) | JAK3JAK1BTKTECTXK | |
| SCHEMBL20183411 | 0.82 | JAK1 (0.60) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL20183409 | 0.82 | JAK1 (0.60) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL28855810 | 0.81 | JAK3 (0.64) | JAK3JAK1BTKTECTXK | |
| SCHEMBL23408967 | 0.80 | JAK3 (0.65) | JAK3JAK1BTKTECTXK | |
| SCHEMBL22909510 | 0.80 | JAK3 (0.65) | JAK3JAK1BTKTECTXK | |
| SCHEMBL23408959 | 0.80 | JAK3 (0.65) | JAK3JAK1BTKTECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136482-A1 | METHOD FOR PREPARING PF06651600 AND INTERMEDIATE USED THEREIN | 江苏艾立康医药科技有限公司 | 2021-07-08 | — | — | WO | disclosed |