Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23611724 | 0.81 | HSD17B10 (1.00) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL29930877 | 0.81 | HSD17B10 (1.00) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL9071981 | 0.79 | HSD17B10 (0.69) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL13929106 | 0.79 | HSD17B10 (0.69) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL1528407 | 0.79 | HSD17B10 (0.69) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL23623364 | 0.77 | HSD17B10 (0.55) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL23611757 | 0.77 | HSD17B10 (0.66) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL17280016 | 0.76 | HSD17B10 (0.65) | HSD17B10ALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL2667067 | 0.75 | HSD17B10 (0.63) | HSD17B10ALDH1A1KDM4EGAADCUN1D1 | |
| SCHEMBL1528432 | 0.75 | HSD17B10 (0.63) | HSD17B10ALDH1A1KDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021138540-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | BERG LLC (US) | 2021-07-08 | — | — | WO | disclosed |