Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356575 | 0.93 | TP53 (0.66) | MAPTPOLBTP53MEN1LMNA | |
| SCHEMBL2363278 | 0.92 | MAPT (0.65) | MAPTPOLBTP53MEN1LMNA | |
| SCHEMBL2362335 | 0.88 | MAPT (0.64) | MAPTPOLBTP53LMNAKDM4E | |
| SCHEMBL2355819 | 0.87 | MAPT (0.65) | MAPTPOLBTP53LMNAKDM4E | |
| SCHEMBL2362291 | 0.86 | TP53 (0.66) | MAPTPOLBTP53MEN1LMNA | |
| SCHEMBL2351588 | 0.85 | TP53 (0.65) | MAPTPOLBTP53MEN1LMNA | |
| SCHEMBL2362570 | 0.81 | TP53 (0.64) | MAPTPOLBTP53MEN1LMNA | |
| SCHEMBL18568061 | 0.80 | KDM4E (0.49) | MAPTPOLBTP53MEN1LMNA | |
| SCHEMBL18568060 | 0.79 | MAPT (0.67) | MAPTPOLBTP53 | |
| SCHEMBL18274592 | 0.78 | MAPT (0.51) | MAPTPOLBTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3135672-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2017-03-01 | — | — | EP | claimed |
| EP-2356109-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2016-12-07 | — | — | EP | claimed |
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | claimed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | claimed |
| EP-2356109-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2011-08-17 | — | — | EP | claimed |
| WO-2010042925-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2010-04-15 | — | — | WO | claimed |
| EP-3135672-B9 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-3135672-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3135672-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-2356109-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2016-12-07 | — | — | EP | disclosed |
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2356109-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010042925-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | PRKCH, PRKCG, PRKCQ | MAPT 1539/4885POLB 3613/4885TP53 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.