Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020232 | 0.85 | KMT2A (0.45) | KMT2ATDP1KDM4EMAPTPOLB | |
| SCHEMBL8802475 | 0.79 | KDM4E (0.54) | KMT2ATDP1KDM4EMAPTQPCT | |
| SCHEMBL25727792 | 0.79 | HDAC6 (0.43) | KMT2ATDP1KDM4EMAPTPOLB | |
| SCHEMBL22533358 | 0.79 | QPCT (0.50) | KMT2ATDP1KDM4EMAPTPOLB | |
| SCHEMBL24501453 | 0.77 | HDAC6 (0.43) | KMT2ATDP1KDM4EMAPTPOLB | |
| SCHEMBL8802469 | 0.77 | KDM4E (0.54) | KMT2ATDP1KDM4EMAPTQPCT | |
| SCHEMBL30952908 | 0.75 | CYP3A4 (0.46) | KMT2ATDP1KDM4EMAPTPOLB | |
| SCHEMBL12589878 | 0.73 | MAPT (0.44) | KMT2ATDP1KDM4EMAPTNPC1 | |
| SCHEMBL29526116 | 0.73 | KDM4E (0.47) | KMT2ATDP1KDM4EMAPTQPCT | |
| SCHEMBL1870024 | 0.73 | KDM4E (0.47) | KMT2ATDP1KDM4EMAPTQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136244-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2021-07-08 | — | — | WO | disclosed |