SCHEMBL2362685

SCHEMBL2362685

CC(N[S+]([O-])C(C)(C)C)c1ccc(C(F)(F)F)nc1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GPR139 Q6DWJ6 1/20 0.40
CYP2C9 P11712 2/20 0.40
NR1I2 O75469 1/20 0.40
TRPV4 Q9HBA0 1/20 0.39
P2RX3 P56373 8/20 0.36
MAPK1 P28482 1/20 0.34
P2RX7 Q99572 3/20 0.34
P2RX2 Q9UBL9 6/20 0.34
TRPV3 Q8NET8 3/20 0.33
CYP2C8 P10632 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
IDH1 O75874 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL998111 1.00 GPR139 (0.40) GPR139CYP2C9NR1I2TRPV4P2RX3
SCHEMBL996960 1.00 GPR139 (0.40) GPR139CYP2C9NR1I2TRPV4P2RX3
SCHEMBL19962272 1.00 GPR139 (0.40) GPR139CYP2C9NR1I2TRPV4P2RX3
SCHEMBL998112 1.00 GPR139 (0.40) GPR139CYP2C9NR1I2TRPV4P2RX3
SCHEMBL346582 1.00 GPR139 (0.40) GPR139CYP2C9NR1I2TRPV4P2RX3
SCHEMBL28656329 1.00 GPR139 (0.40) GPR139CYP2C9NR1I2TRPV4P2RX3
SCHEMBL28656330 1.00 GPR139 (0.40) GPR139CYP2C9NR1I2TRPV4P2RX3
SCHEMBL14831456 0.88 IDH1 (0.36) GPR139CYP2C9NR1I2IDH1
SCHEMBL14831455 0.88 IDH1 (0.36) GPR139CYP2C9NR1I2IDH1
SCHEMBL27966106 0.88 IDH1 (0.36) GPR139CYP2C9NR1I2IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110256418-B 1, 3-thiazol-2-yl substituted benzamides 拜耳公司 2023-01-20 CN disclosed
CN-107207507-B 1, 3-thiazol-2-yl substituted benzamides 拜耳公司 2020-11-06 CN disclosed
EP-2358371-A1 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN Merck Sharp & Dohme Corp. (US) 2011-08-24 EP disclosed
EP-2215048-A1 P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN Merck Sharp & Dohme Corp. (US) 2010-08-11 EP disclosed
WO-2010051188-A1 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN MERCK SHARP & DOHME CORP. (US) 2010-05-06 WO disclosed
WO-2009058299-A1 P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN MERCK & CO., INC. (US) 2009-05-07 WO disclosed