Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 7/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23629251 | 0.80 | KDM5A (0.50) | KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL23629273 | 0.79 | BTK (0.54) | KDM5AKDM5BKDM4CPLK4CHEK1 | |
| SCHEMBL29738256 | 0.78 | TSHR (0.49) | MEN1KMT2AKDM5AKDM5BMAP2K1 | |
| SCHEMBL26233949 | 0.78 | TSHR (0.49) | MEN1KMT2AKDM5AKDM5BMAP2K1 | |
| SCHEMBL23629250 | 0.78 | PTPN11 (0.43) | PIK3C3SLC40A1KDM5AKDM5BKDM4C | |
| SCHEMBL29712599 | 0.73 | PLK4 (0.64) | MEN1KMT2APLK4CHEK1AURKA | |
| SCHEMBL18937563 | 0.73 | PLK4 (0.64) | MEN1KMT2APLK4CHEK1AURKA | |
| SCHEMBL8568156 | 0.69 | PREP (0.47) | MEN1KMT2ASLC40A1CLK4 | |
| SCHEMBL3865778 | 0.69 | PTPN1 (0.40) | PIK3C3ROCK2PTK2 | |
| SCHEMBL23629246 | 0.69 | SLC40A1 (0.38) | MEN1KMT2APIK3C3SLC40A1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12371430-B2 | 5-morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives | MERCK PATENT GMBH (DE) | 2025-07-29 | — | — | US | claimed |
| US-20210355123-A1 | 5-Morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives | MERCK PATENT GMBH (DE) | 2021-11-18 | — | — | US | claimed |
| EP-3846904-A1 | 5-MORPHOLIN-4-YL-PYRAZOLO[4,3-B]PYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2021-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355123-A1 | 5-Morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives | ATR, CDK1, CDKN1A | MEN1 464/4885KMT2A 2005/4885PIK3C3 1091/4885 |
| US-12371430-B2 | 5-morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives | ATR, CDK1, CDKN1A | MEN1 464/4885KMT2A 2005/4885PIK3C3 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.