Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 5/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18601369 | 0.85 | P2RX4 (0.36) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 | |
| SCHEMBL31350302 | 0.74 | P2RX4 (0.41) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 | |
| SCHEMBL2204621 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 | |
| SCHEMBL30643764 | 0.73 | P2RX4 (0.38) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 | |
| SCHEMBL11168819 | 0.73 | P2RX4 (0.38) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 | |
| SCHEMBL10743523 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 | |
| SCHEMBL30250427 | 0.68 | BRD4 (0.40) | SMN1; SMN2MAPK1OPRM1OPRD1OPRK1 | |
| SCHEMBL6991005 | 0.68 | BRD4 (0.40) | SMN1; SMN2MAPK1OPRM1OPRD1OPRK1 | |
| Propionic Acid SCHEMBL31424601 | 0.68 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 | |
| SCHEMBL11412073 | 0.67 | P2RX4 (0.71) | SMN1; SMN2LMNAMAPK1P2RX4P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3847166-A1 | POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS | Femtogenix Limited (GB) | 2021-07-14 | — | — | EP | disclosed |