Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.54 |
| ▸ | KDM6B | O15054 | 1/20 | 0.54 |
| ▸ | KDM5C | P41229 | 1/20 | 0.54 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.54 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750019 | 0.85 | HRH3 (0.57) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL20938625 | 0.84 | HRH3 (0.59) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL5929302 | 0.83 | PIK3CA (0.54) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL2028882 | 0.83 | PIK3CA (0.57) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL1021177 | 0.82 | HRH3 (0.54) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL17843238 | 0.82 | HRH3 (0.54) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL31704530 | 0.82 | PIK3CA (0.74) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL1516978 | 0.82 | PIK3CA (0.74) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| Hydrochloric Acid SCHEMBL23630502 | 0.81 | HRH3 (0.53) | HRH3KDM4EKDM4CKDM6BKDM5C | |
| SCHEMBL390338 | 0.81 | HRH3 (0.56) | HRH3KDM4EKDM4CKDM6BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2023-03-23 | — | — | US | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | VHL, SMARCC2, SMARCC1 | HRH3 2879/4885KDM4E 178/4885KDM4C 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.