Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30075144 | 1.00 | GPR119 (0.40) | GPR119TEAD1LIPEMMP2MMP13 | |
| SCHEMBL23632536 | 0.91 | MCL1 (0.39) | GPR119LIPEGHSRNR1H2NR1H3 | |
| SCHEMBL23632234 | 0.91 | MCL1 (0.39) | GPR119LIPEGHSRNR1H2NR1H3 | |
| SCHEMBL30842554 | 0.88 | GPR119 (0.41) | GPR119TEAD1LIPEMMP2MMP13 | |
| SCHEMBL23631924 | 0.87 | TEAD1 (0.42) | GPR119TEAD1LIPEMMP2MMP13 | |
| SCHEMBL28586792 | 0.87 | TEAD1 (0.42) | TEAD1LIPEMMP2MMP13LIPG | |
| SCHEMBL31599294 | 0.85 | TACR1 (0.42) | GPR119NR1H2NR1H3TACR1 | |
| SCHEMBL30075118 | 0.85 | TACR1 (0.42) | GPR119NR1H2NR1H3TACR1 | |
| SCHEMBL28537462 | 0.85 | TACR1 (0.42) | GPR119NR1H2NR1H3TACR1 | |
| SCHEMBL23632615 | 0.80 | GPR119 (0.39) | GPR119TEAD1LIPELIPGGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072521-B | ROR gamma t inhibitor and application thereof in medicines | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-113072542-B | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| WO-2021139595-A1 | RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2021-07-15 | — | — | WO | disclosed |
| CN-113072521-A | ROR gamma t inhibitor and application thereof in medicine | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |