Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2328458 | 0.89 | MCHR1 (0.49) | HDAC3HDAC1HDAC2MAPK1ALDH1A1 | |
| SCHEMBL23638281 | 0.83 | HDAC3 (0.47) | HDAC3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL521030 | 0.83 | HDAC3 (0.52) | HDAC3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL29041989 | 0.83 | MCHR1 (0.39) | HDAC3HDAC1HDAC2MAPK1ALOX15 | |
| SCHEMBL29985547 | 0.80 | LMNA (0.49) | HDAC3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL15681625 | 0.79 | HDAC3 (0.61) | HDAC3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL23632999 | 0.79 | KDM4E (0.42) | ALDH1A1HTTTSHRLMNAKMT2A | |
| SCHEMBL23638498 | 0.79 | KDM4E (0.42) | ALDH1A1HTTTSHRLMNAKMT2A | |
| SCHEMBL521032 | 0.78 | LMNA (0.48) | HDAC3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL146444 | 0.76 | HDAC8 (0.38) | ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901664-B | Pyridone compounds and uses thereof | 南京再明医药有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| WO-2023198114-A1 | ALK2 KINASE INHIBITOR | 杭州邦顺制药有限公司 | 2023-10-19 | — | — | WO | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |
| WO-2022206730-A1 | PYRIMIDOPYRAZINE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-06 | — | — | WO | disclosed |
| CN-115141202-A | Pyrimidopyrazinone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-04 | — | — | CN | disclosed |
| CN-114901664-A | Pyridone compound and application thereof | 江苏先声药业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |