Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6418166 | 0.84 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL20221694 | 0.81 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL2542298 | 0.81 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL20054317 | 0.81 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL16994173 | 0.81 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL16994161 | 0.81 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL15116890 | 0.81 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL20811182 | 0.81 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL23377566 | 0.81 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL1334631 | 0.79 | NR1H2 (0.39) | NR1H2CHRM2CHRM1CHRM3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059827-B2 | Compounds and compositions useful for treating disorders related to NTRK | BLUEPRINT MEDICINES CORPORATION (US) | 2021-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059827-B2 | Compounds and compositions useful for treating disorders related to NTRK | NTRK2, NTRK3, NTRK1 | NR1H2 1471/4885CHRM2 3575/4885CHRM1 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.