Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.41 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14673452 | 0.92 | SYK (0.61) | SYKMAPK8MAPK10MAPK14PIP5K1C | |
| SCHEMBL14673478 | 0.86 | SYK (0.68) | SYKMAPK8MAPK10MAPK14ALDH1A1 | |
| SCHEMBL17113481 | 0.76 | SYK (1.00) | SYKMAPK8MAPK10PIP5K1CPIK3CA | |
| SCHEMBL14673689 | 0.76 | KARS1 (0.52) | SYKPDE5AMAP3K12 | |
| SCHEMBL17113465 | 0.75 | SYK (0.72) | SYKMAPK10ALDH1A1MEN1KMT2A | |
| SCHEMBL14680991 | 0.74 | SYK (0.51) | SYKPDE5AKDRKCNH2GSK3B | |
| SCHEMBL2227682 | 0.74 | SYK (0.55) | SYKMAPK8ALDH1A1MEN1KMT2A | |
| SCHEMBL2227336 | 0.72 | SYK (0.50) | SYKPIK3CAKDRKDM4ERAB9A | |
| SCHEMBL8798398 | 0.72 | SCN9A (0.48) | MAPK8MAPK10ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14680993 | 0.71 | SYK (0.57) | SYKMAPK10KDRMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523952-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | AB Science (FR) | 2012-11-21 | — | — | EP | claimed |
| WO-2011086085-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | AB SCIENCE (FR) | 2011-07-21 | — | — | WO | claimed |