Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FOXM1 | Q08050 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21842124 | 0.79 | SMN1; SMN2 (0.54) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL21842364 | 0.79 | SMN1; SMN2 (0.54) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL21842123 | 0.79 | SMN1; SMN2 (0.54) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL23634800 | 0.78 | OPRL1 (0.36) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL13419170 | 0.77 | NPC1 (0.47) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL3530758 | 0.77 | KDM4E (0.53) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL3536193 | 0.77 | KDM4E (0.53) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL2774793 | 0.77 | KDM4E (0.53) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL6533951 | 0.77 | KDM4E (0.53) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL455085 | 0.77 | RAD52 (0.56) | KDM4EALDH1A1RAD52CXCR4CXCL12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848363-B1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | MEDSHINE DISCOVERY INC (CN) | 2023-07-19 | — | — | EP | disclosed |
| EP-3848363-A1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | Medshine Discovery Inc. (CN) | 2021-07-14 | — | — | EP | disclosed |