Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | APP | P05067 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090481 | 0.80 | ALDH1A1 (0.42) | POLBKDM4EPDE10AGSK3BALDH1A1 | |
| SCHEMBL9109729 | 0.77 | POLB (0.53) | POLBPTPN1KDM4EALDH1A1MAPT | |
| SCHEMBL29315129 | 0.74 | ALDH1A1 (0.46) | POLBPTPN1KDM4EALDH1A1MAPT | |
| SCHEMBL12278352 | 0.73 | CES1 (0.39) | KDM4EALDH1A1MAPT | |
| SCHEMBL4424706 | 0.72 | ALDH2 (0.35) | POLBKDM4EALDH1A1 | |
| SCHEMBL2094158 | 0.72 | ALDH1A1 (0.42) | POLBKDM4EALDH1A1MAPT | |
| SCHEMBL8129734 | 0.71 | KDM4E (0.42) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8126781 | 0.71 | ALDH1A1 (0.38) | PTPN1KDM4EALDH1A1MAPTAPP | |
| SCHEMBL23634794 | 0.70 | MAPT (0.31) | KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL23918626 | 0.69 | CYP1A2 (0.45) | HTR2CPOLBPTPN1KDM4EGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848363-B1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | MEDSHINE DISCOVERY INC (CN) | 2023-07-19 | — | — | EP | disclosed |
| EP-3848363-A1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | Medshine Discovery Inc. (CN) | 2021-07-14 | — | — | EP | disclosed |