Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.44 |
| ▸ | F10 | P00742 | 7/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.40 |
| ▸ | WNT1 | P04628 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | CLK3 | P49761 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18996612 | 0.90 | DYRK1A (0.48) | DYRK1AF10GSK3BWNT1CLK2 | |
| SCHEMBL23635137 | 0.79 | DYRK1A (0.39) | DYRK1AF10GSK3BWNT1CLK2 | |
| SCHEMBL17027809 | 0.77 | DYRK1A (0.42) | DYRK1AF10GSK3BWNT1CLK2 | |
| SCHEMBL17027818 | 0.77 | F10 (0.54) | DYRK1AF10GSK3BWNT1CLK2 | |
| SCHEMBL17027858 | 0.76 | DYRK1A (0.47) | DYRK1AF10GSK3BWNT1CLK2 | |
| SCHEMBL18979437 | 0.75 | PIK3CA (0.52) | DYRK1AF10GSK3B | |
| SCHEMBL18979456 | 0.74 | F10 (0.61) | DYRK1AF10GSK3BWNT1CLK2 | |
| SCHEMBL17027778 | 0.72 | DEGS1 (0.47) | — | |
| SCHEMBL18979420 | 0.72 | F10 (0.61) | DYRK1AF10GSK3BWNT1CLK2 | |
| SCHEMBL18979422 | 0.70 | F10 (0.62) | DYRK1AF10GSK3BWNT1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107909-B1 | ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS | FROST BIOLOGIC INC (US) | 2021-07-14 | — | — | EP | disclosed |