Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.50 |
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16447382 | 0.88 | PARP10 (0.58) | PDE4BPDE4DPDE4APDE4CPARP10 | |
| SCHEMBL6460615 | 0.88 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPARP10 | |
| SCHEMBL17204380 | 0.83 | PARP15 (0.55) | PDE4BPDE4DPDE4APDE4CPARP10 | |
| SCHEMBL30476625 | 0.83 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPARP10 | |
| SCHEMBL17204413 | 0.82 | KDM4E (0.52) | PDE4BPARP10PARP15PARP2SMN1; SMN2 | |
| SCHEMBL17908054 | 0.80 | MEN1 (0.55) | MRGPRX4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20053762 | 0.80 | NR1H4 (0.52) | PDE4BPDE4DPDE4APDE4CPARP10 | |
| SCHEMBL17204548 | 0.80 | ESR1 (0.48) | PARP10PARP15PARP2 | |
| SCHEMBL8901981 | 0.79 | PARP10 (0.68) | PDE4BPDE4DPDE4APDE4CPARP10 | |
| SCHEMBL6456302 | 0.78 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4742026-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| EP-1606261-A1 | NOVEL PROCESS FOR THE PREPARATION OF ROFLUMILAST | ALTANA Pharma AG (DE) | 2005-12-21 | — | — | EP | claimed |
| WO-2004080967-A1 | NOVEL PROCESS FOR THE PREPARATION OF ROFLUMILAST | ALTANA PHARMA AG (DE) | 2004-09-23 | — | — | WO | claimed |
| EP-1606261-A1 | NOVEL PROCESS FOR THE PREPARATION OF ROFLUMILAST | ALTANA Pharma AG (DE) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080967-A1 | NOVEL PROCESS FOR THE PREPARATION OF ROFLUMILAST | ALTANA PHARMA AG (DE) | 2004-09-23 | — | — | WO | disclosed |