⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21150125 | 0.79 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL21149285 | 0.79 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL9665646 | 0.77 | TDP1 (0.39) | — | |
| SCHEMBL1106979 | 0.77 | — | — | |
| SCHEMBL15478609 | 0.74 | — | — | |
| SCHEMBL3641120 | 0.74 | — | — | |
| SCHEMBL8141423 | 0.72 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL16266424 | 0.72 | — | — | |
| SCHEMBL18117417 | 0.72 | — | — | |
| SCHEMBL10125333 | 0.72 | SMN1; SMN2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192728-A1 | MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY (US) | 2023-06-22 | — | — | US | disclosed |
| US-20210214378-A1 | MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY (US) | 2021-07-15 | — | — | US | disclosed |