Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364048 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL13645769 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL22296593 | 0.77 | EPHX1 (0.39) | SMN1; SMN2MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL860139 | 0.77 | — | — | |
| SCHEMBL29202927 | 0.77 | EPHX1 (0.42) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12330393 | 0.76 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1EPHX1MAPTACACB | |
| SCHEMBL20307776 | 0.76 | EPHX1 (0.38) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL14943744 | 0.75 | ALDH1A1 (0.34) | SMN1; SMN2LMNAALDH1A1EPHX1MAPT | |
| SCHEMBL13684345 | 0.75 | MEN1 (0.47) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL13686217 | 0.75 | MEN1 (0.47) | SMN1; SMN2MEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528902-A1 | OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092187-A1 | OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2011-08-04 | — | — | WO | disclosed |