Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23639021 | 0.90 | SCN9A (0.38) | SCN9ASLC6A4CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL23638877 | 0.79 | SCN9A (0.41) | SCN9ACHRNB2CHRNA4 | |
| SCHEMBL23639020 | 0.79 | SCN9A (0.39) | SCN9ASLC6A4CHRNB2CHRNA4HTR2C | |
| SCHEMBL23638876 | 0.78 | SCN9A (0.47) | SCN9ASLC6A4CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL20063500 | 0.78 | SCN9A (0.47) | SCN9AHTR2C | |
| SCHEMBL23638882 | 0.77 | POLQ (0.36) | SCN9A | |
| SCHEMBL23638891 | 0.76 | IDO1 (0.39) | IDO1 | |
| SCHEMBL23638947 | 0.76 | SCN9A (0.48) | SCN9A | |
| SCHEMBL21311660 | 0.76 | SLC6A4 (0.45) | SCN9ASLC6A4CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL23639105 | 0.75 | SCN9A (0.49) | SCN9ASLC6A4CHRNB2CHRNA4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210214336-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2021-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210214336-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | SCN1B, CACNA1A, SCN1A | SCN9A 34/4885SLC6A4 309/4885CHRNB2 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.