Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 10/20 | 0.33 |
| ▸ | TACR1 | P25103 | 7/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23638877 | 0.88 | SCN9A (0.41) | POLQSCN9ATACR1 | |
| SCHEMBL20063500 | 0.80 | SCN9A (0.47) | SCN9AHTR2A | |
| SCHEMBL23638881 | 0.79 | SCN9A (0.35) | SCN9ATACR1 | |
| SCHEMBL23639021 | 0.78 | SCN9A (0.38) | SCN9A | |
| SCHEMBL23638874 | 0.77 | SCN9A (0.40) | SCN9A | |
| SCHEMBL23639056 | 0.77 | SCN9A (0.43) | SCN9A | |
| SCHEMBL23639107 | 0.76 | SCN9A (0.44) | POLQSCN9A | |
| SCHEMBL23638947 | 0.76 | SCN9A (0.48) | SCN9A | |
| SCHEMBL23638879 | 0.76 | SCN9A (0.40) | SCN9ATACR1 | |
| SCHEMBL23638885 | 0.75 | SCN9A (0.42) | SCN9ATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210214336-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2021-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210214336-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | SCN1B, CACNA1A, SCN1A | POLQ 4845/4885SCN9A 34/4885TACR1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.