Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | ACACB | O00763 | 7/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363925 | 1.00 | KCNH2 (0.72) | KCNH2PTGS1SLC6A2SLC6A4ACACB | |
| SCHEMBL3664766 | 0.95 | KCNH2 (0.67) | KCNH2PTGS1SLC6A2SLC6A4ACACB | |
| SCHEMBL3664769 | 0.95 | KCNH2 (0.67) | KCNH2PTGS1SLC6A2SLC6A4ACACB | |
| SCHEMBL2316010 | 0.92 | KCNH2 (0.68) | KCNH2PTGS1SLC6A2SLC6A4ACACB | |
| SCHEMBL3028831 | 0.88 | KCNH2 (0.58) | KCNH2PTGS1SLC6A2SLC6A4ACACB | |
| SCHEMBL3028835 | 0.88 | KCNH2 (0.58) | KCNH2PTGS1SLC6A2SLC6A4ACACB | |
| SCHEMBL3038267 | 0.85 | KCNH2 (0.55) | KCNH2PTGS1SLC6A2SLC6A4CHRM4 | |
| SCHEMBL3038264 | 0.85 | KCNH2 (0.55) | KCNH2PTGS1SLC6A2SLC6A4CHRM4 | |
| SCHEMBL22527428 | 0.82 | KCNH2 (0.57) | KCNH2PTGS1SLC6A2SLC6A4ACACB | |
| SCHEMBL2056202 | 0.81 | KCNH2 (0.58) | KCNH2PTGS1SLC6A2SLC6A4ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552188-B2 | Epoxy compound and method for manufacturing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-08 | — | — | US | claimed |
| US-20130072683-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-21 | — | — | US | claimed |
| EP-2144899-B1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2011-12-07 | — | — | EP | claimed |
| US-20100217005-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | claimed |
| EP-2144899-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-01-20 | — | — | EP | claimed |
| WO-2008140090-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-11-20 | — | — | WO | claimed |
| WO-2020202205-A1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1,1-DIALKYLETHANE-1,2-DIOLS AS USEFUL INTERMEDIATES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2020-10-08 | — | — | WO | disclosed |
| EP-3275862-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-01-31 | — | — | EP | disclosed |
| EP-2528896-B1 | SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2014-08-27 | — | — | EP | disclosed |
| EP-2528896-B1 | SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2014-08-27 | — | — | EP | disclosed |
| US-8598358-B2 | Synthetic intermediate of oxazole compound and method for producing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-12-03 | — | — | US | disclosed |
| US-8552188-B2 | Epoxy compound and method for manufacturing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| US-20130072683-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-21 | — | — | US | disclosed |
| US-20120302757-A1 | SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-11-29 | — | — | US | disclosed |
| EP-2144899-B1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2011-12-07 | — | — | EP | disclosed |
| WO-2011093529-A1 | SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-04 | — | — | WO | disclosed |
| WO-2011093529-A1 | SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-04 | — | — | WO | disclosed |
| US-20100217005-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| EP-2144899-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008140090-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302757-A1 | SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME | GLP1R, HBB, OXA1L | KCNH2 2417/4885PTGS1 3299/4885SLC6A2 4032/4885 |
| US-20130072683-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | SQLE, CYP2E1, CYP1A1 | KCNH2 1413/4885PTGS1 100/4885SLC6A2 4882/4885 |
| US-20100217005-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | SQLE, CYP2E1, CYP1A1 | KCNH2 1327/4885PTGS1 108/4885SLC6A2 4879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.