SCHEMBL2363979

SCHEMBL2363979

CC1OC(c2ccc(C(F)(F)F)cc2)c2c1nc1c(c2C2CCN(C(=O)OCc3ccccc3)CC2)C(O[Si](C)(C)C(C)(C)C)CC(C)(C)C1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CETP P11597 18/20 0.56
RORC P51449 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL972937 1.00 CETP (0.56) CETPRORC
SCHEMBL972744 0.89 CETP (0.70) CETP
SCHEMBL973115 0.85 CETP (0.40) CETP
SCHEMBL12921459 0.83 CETP (0.47) CETP
SCHEMBL12444159 0.83 CETP (0.47) CETP
SCHEMBL12921461 0.82 CETP (0.47) CETP
SCHEMBL12444150 0.82 CETP (0.47) CETP
SCHEMBL971327 0.82 CETP (0.48) CETP
SCHEMBL2364438 0.80 CETP (0.61) CETP
SCHEMBL969737 0.80 CETP (0.61) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268644-B1 TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION BOEHRINGER INGELHEIM INT (DE) 2011-08-17 EP disclosed