Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24302320 | 0.79 | HRH4 (0.35) | HRH3ALDH1A1 | |
| SCHEMBL24302785 | 0.79 | HRH4 (0.35) | HRH3ALDH1A1 | |
| SCHEMBL23640164 | 0.79 | HRH4 (0.35) | HRH3ALDH1A1 | |
| SCHEMBL23640445 | 0.78 | — | — | |
| SCHEMBL24302321 | 0.78 | — | — | |
| SCHEMBL24302333 | 0.78 | NOS3 (0.32) | — | |
| SCHEMBL23639977 | 0.78 | NOS3 (0.32) | — | |
| SCHEMBL24302261 | 0.75 | HTR1B (0.39) | CHRNB2CHRNA4HTR1B | |
| SCHEMBL23640163 | 0.75 | HTR1B (0.39) | CHRNB2CHRNA4HTR1B | |
| SCHEMBL20180434 | 0.72 | MAPT (0.35) | MAPTHTR7HRH3LTA4HKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |