Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28025239 | 0.93 | ALDH1A1 (0.71) | ALDH1A1TLR8NR4A2TSHRGPBAR1 | |
| Dodecane SCHEMBL28937946 | 0.91 | ALDH1A1 (0.68) | ALDH1A1TLR8GPBAR1NPC1POLB | |
| Quinoline SCHEMBL28202501 | 0.91 | ALDH1A1 (0.68) | ALDH1A1TLR8NR4A2TSHRGPBAR1 | |
| Quinoline SCHEMBL27987363 | 0.91 | ALDH1A1 (0.68) | ALDH1A1TLR8GPBAR1NPC1POLB | |
| Decane SCHEMBL9763188 | 0.91 | ALDH1A1 (0.68) | ALDH1A1TLR8GPBAR1NPC1POLB | |
| Quinoline SCHEMBL27417695 | 0.91 | ALDH1A1 (0.68) | ALDH1A1TLR8GPBAR1NPC1POLB | |
| Quinoline SCHEMBL11220317 | 0.89 | ALDH1A1 (0.65) | ALDH1A1TLR8GPBAR1NPC1POLB | |
| Quinoline SCHEMBL28162427 | 0.89 | ALDH1A1 (0.71) | ALDH1A1TLR8NR4A2TSHRGPBAR1 | |
| Quinoline SCHEMBL8810836 | 0.87 | ALDH1A1 (0.74) | ALDH1A1NR4A2TSHRNPC1POLB | |
| Quinoxaline SCHEMBL27798817 | 0.85 | TSHR (0.48) | ALDH1A1TLR8TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106496120-A | A kind of preparation method of cinchocaine hydrochloride | 昆明源瑞制药有限公司 | 2017-03-15 | — | — | CN | claimed |
| CN-110066245-A | A kind of quinoline carboxylic acid ester's compound and preparation method thereof and purposes | 山东省联合农药工业有限公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-109942488-A | A kind of quinoline carboxylic acid ester's compound and preparation method thereof and purposes | 山东省联合农药工业有限公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-104685976-B | The manufacturing method of conductive pattern | 东丽株式会社 | 2019-05-31 | — | — | CN | disclosed |
| CN-106496120-A | A kind of preparation method of cinchocaine hydrochloride | 昆明源瑞制药有限公司 | 2017-03-15 | — | — | CN | disclosed |
| CN-104685976-A | Conductive pattern fabrication method | TORAY INDUSTRIES | 2015-06-03 | — | — | CN | disclosed |
| US-8008501-B2 | Inhibit the Immunoglobulin E (IgE) receptor signaling cascade; associated with mast and/or basophil cell degranulation such as allergic diseases, scarring, inflammation; e.g. 5-Methyl-3-phenyl-4-isoxazolecarboxylic acid, 2-methyl-4-quinolinyl Ester | RIGEL PHARMACEUTICALS, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| EP-1675850-B1 | QUINOLINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2008-06-25 | — | — | EP | disclosed |
| CN-1927839-A | Compound of 1,4-di(arylamido substituted alkylamino)-5,8-dihydroxyanthraquinone and preparation method thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2007-03-14 | — | — | CN | disclosed |
| EP-1675850-A1 | QUINOLINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005033103-A1 | QUINOLINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2005-04-14 | — | — | WO | disclosed |
| CN-1097459-C | Diazepino-indoles as phosphodiesterase IV inhibitors | JOUVEINAL INST RECH (FR) | 2003-01-01 | — | — | CN | disclosed |
| CN-1361768-A | Metabotropic glutamate receptor antagonists and their use for treating central nervous system disorders | NPS PHARMA INC (US) | 2002-07-31 | — | — | CN | disclosed |
| CN-1067685-C | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 2001-06-27 | — | — | CN | disclosed |
| CN-1053189-C | pyridazino quinoline compounds | ZENECA LTD (GB) | 2000-06-07 | — | — | CN | disclosed |
| CN-1238777-A | Erythromycin A derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 1999-12-15 | — | — | CN | disclosed |
| CN-1171787-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1998-01-28 | — | — | CN | disclosed |
| CN-1160352-A | Diaza * -oxindoles as phosphodiesterase IV inhibitors | JOUVEINAL INST RECH (FR) | 1997-09-24 | — | — | CN | disclosed |
| CN-1138332-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1996-12-18 | — | — | CN | disclosed |
| CN-1069729-A | Dihydropyridazinone, pyridazinone and related compound thereof as sterilant | ROHM & HAAS (US) | 1993-03-10 | — | — | CN | disclosed |