Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3327903 | 0.89 | TRPV1 (0.38) | TRPV1 | |
| SCHEMBL3322270 | 0.84 | TRPV1 (0.54) | TRPV1 | |
| SCHEMBL4140742 | 0.77 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL4137513 | 0.77 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL4125522 | 0.76 | TRPV1 (0.45) | TRPV1 | |
| SCHEMBL3319450 | 0.73 | TRPV1 (0.75) | TRPV1 | |
| SCHEMBL2317444 | 0.73 | TRPV1 (0.75) | TRPV1 | |
| SCHEMBL4133142 | 0.73 | TRPV1 (0.41) | TRPV1 | |
| SCHEMBL3766306 | 0.73 | TRPV1 (0.41) | TRPV1 | |
| SCHEMBL14421632 | 0.69 | TRPV1 (0.43) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352727-A1 | TRPV1 ANTAGONISTS | Abbott Laboratories (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010045402-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2010-04-22 | — | — | WO | disclosed |