Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29943946 | 1.00 | CKS1B (0.47) | CKS1BSKP1SKP2GPR119LRRK2 | |
| SCHEMBL29943888 | 0.89 | CKS1B (0.49) | CKS1BSKP1SKP2GPR119LRRK2 | |
| SCHEMBL23630501 | 0.89 | CKS1B (0.49) | CKS1BSKP1SKP2GPR119LRRK2 | |
| SCHEMBL23630374 | 0.85 | KDM4E (0.46) | ACHEKDM4E | |
| SCHEMBL23630375 | 0.85 | KDM4E (0.46) | ACHEKDM4E | |
| SCHEMBL20128887 | 0.84 | GPR119 (0.52) | CKS1BSKP1SKP2GPR119ABCB1 | |
| SCHEMBL20214374 | 0.84 | GPR119 (0.52) | CKS1BSKP1SKP2GPR119ABCB1 | |
| SCHEMBL22579215 | 0.81 | CKS1B (0.50) | CKS1BSKP1SKP2GPR119ABCB1 | |
| SCHEMBL22579252 | 0.80 | RET (0.52) | CKS1BSKP1SKP2WNT3A | |
| SCHEMBL15228419 | 0.79 | GPR119 (0.56) | CKS1BSKP1SKP2GPR119LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |