Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586425 | 0.87 | CYP3A4 (0.38) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL7094910 | 0.82 | CYP3A4 (0.41) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL1082749 | 0.82 | CYP3A4 (0.41) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL8207148 | 0.82 | CYP3A4 (0.41) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL3407885 | 0.80 | TSHR (0.36) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL11444238 | 0.80 | CYP3A4 (0.39) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL29506833 | 0.80 | CYP3A4 (0.39) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL28427366 | 0.80 | CYP3A4 (0.39) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| Ammonia Solution, Strong SCHEMBL10836805 | 0.80 | CYP3A4 (0.39) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL28761387 | 0.80 | CYP3A4 (0.39) | CYP3A4TSHRMAPTCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108794334-B | Method for preparing difluoroacetic acid ester through gas-solid phase reaction | 浙江省化工研究院有限公司 | 2021-05-11 | — | — | CN | claimed |
| EP-1644314-B1 | METHOD FOR PRODUCING DIFLUORO-ACETYL-ACETIC ACID ALKYLESTERS | BAYER CROPSCIENCE AG (DE) | 2011-08-10 | — | — | EP | claimed |
| US-7585998-B2 | Method for producing difluoro-acetyl-acetic acid alkylesters | BAYER CROPSCIENCE AG (DE) | 2009-09-08 | — | — | US | claimed |
| US-20060149091-A1 | Method for producing difluoro-acetyl-acetic acid alkylesters | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-07-06 | — | — | US | claimed |
| EP-1670742-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Ranbaxy Laboratories Limited (IN) | 2006-06-21 | — | — | EP | claimed |
| WO-2005026095-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-24 | — | — | WO | claimed |
| US-7585998-B2 | Method for producing difluoro-acetyl-acetic acid alkylesters | BAYER CROPSCIENCE AG (DE) | 2009-09-08 | — | — | US | disclosed |
| CN-100427454-C | Process for preparing alkyl difluoroacetoacetates | BAYER CROPSCIENCE AG (DE) | 2008-10-22 | — | — | CN | disclosed |
| CN-1812959-A | Method for producing difluoro-acetyl-acetic acid alkylesters | BAYER CROPSCIENCE AG (DE) | 2006-08-02 | — | — | CN | disclosed |
| US-20060149091-A1 | Method for producing difluoro-acetyl-acetic acid alkylesters | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1670742-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Ranbaxy Laboratories Limited (IN) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005026095-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-24 | — | — | WO | disclosed |
| US-6583313-B1 | Methyl and ethyl esters of trifluoroacetic acid or chloro-difluoroacetic acid; catalytic esterification of acid chlorides with excess of alcohol; high purity without distillating | SOLVAY FLUOR UND DERIVATE GMBH (DE) | 2003-06-24 | — | — | US | disclosed |
| US-4892962-A | FROM ALLYL DIFLUOROACETATES AND A MONOCHLORO=SILANE, ADDITION POLYMERS | CIBA-GEIGY CORPORATION (US) | 1990-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060149091-A1 | Method for producing difluoro-acetyl-acetic acid alkylesters | APEH, ACACA, NAT1 | CYP3A4 343/4885TSHR 1158/4885MAPT 4299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.