SCHEMBL236431

SCHEMBL236431

O=C(O)CN1C(=O)CCC1=O

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
KMT2A Q03164 3/20 0.50
MEN1 O00255 2/20 0.50
GSK3A P49840 1/20 0.50
GSK3B P49841 1/20 0.50
SMN1; SMN2 Q16637 3/20 0.48
RAB9A P51151 1/20 0.48
CA12 O43570 1/20 0.45
CA9 Q16790 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.44
ALDH1A1 P00352 2/20 0.43
ALOX12 P18054 1/20 0.43
GAA P10253 1/20 0.42
HTT P42858 1/20 0.42
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene Glycol SCHEMBL27986613 0.93 TSHR (0.50) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL4600179 0.90 TSHR (0.52) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL23077911 0.81 TSHR (0.44) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL121100 0.81 TSHR (0.40) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL1269478 0.80 RAB9A (0.42) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL25890753 0.80 HSD17B10 (0.41) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL5002371 0.78 SMN1; SMN2 (0.56) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL6037020 0.77 SMN1; SMN2 (0.43) TSHRKMT2AMEN1GSK3AGSK3B
SCHEMBL5091798 0.77 TSHR (0.44) TSHRKMT2AMEN1SMN1; SMN2RAB9A
SCHEMBL7773775 0.77 SMN1; SMN2 (0.43) TSHRKMT2AMEN1GSK3AGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 775 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118027176-B Human beta 2-microglobulin mutant 郑春杨 2024-12-24 CN claimed
CN-118027176-A Human beta 2-microglobulin mutant 郑春杨 2024-05-14 CN claimed
CN-117603335-A Human serum amyloid A mutant 北京春雷杰创生物科技有限公司 2024-02-27 CN claimed
CN-117486998-A Dipolyethylene glycol-insulin conjugate and preparation method and application thereof 中山大学 2024-02-02 CN claimed
CN-116183763-A9 Impurity detection method of piracetam injection 北京星昊盈盛药业有限公司 2024-01-05 CN claimed
CN-116867795-A Novel method for producing antibody-immunostimulant conjugate 第一三共株式会社 2023-10-10 CN claimed
WO-2023129438-A1 HYDROGEL COMPOSITIONS FOR USE FOR DEPLETION OF TUMOR ASSOCIATED MACROPHAGES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2023-07-06 WO claimed
CN-109810198-B Site-specific GLP-2 conjugates utilizing immunoglobulin fragments 韩美科学株式会社 2023-06-06 CN claimed
CN-116183763-A Impurity detection method of piracetam injection 北京星昊盈盛药业有限公司 2023-05-30 CN claimed
US-20230090790-A1 LONG-ACTING CONJUGATES OF GLP-2 DERIVATIVES HANMI PHARM. CO., LTD. (KR) 2023-03-23 US claimed
US-20040180054-A1 Physiologically active polypeptide conjugate having prolonged in vivo half-life HANMI PHARM. CO., LTD. 2004-09-16 US claimed
WO-2003070805-A1 HYDROLYTICALLY DEGRADABLE ALKYLENE OXIDE BASED POLYMERS NEKTAR THERAPEUTICS AL, CORPORATION (US) 2003-08-28 WO claimed
US-20030023023-A1 Hydrolytically degradable polymers and hydrogels made therefrom SHEARWATER CORPORATION 2003-01-30 US claimed
EP-0792893-B1 Polyolefins modified with an unsaturated polyfunctional monomer containing an imide group and an ester group POLIMERI EUROPA SPA (IT) 2002-07-17 EP claimed
US-6348558-B1 OLIGOMERS COMPRISING ALKYLENE OXIDE MONOMERS AND CARBONATE LINKAGES; POLYCARBONATEETHER COPOLYMERS; DRUG DELIVERY; CONJUGATED TO PEPTIDES OR PROTEINS FOR REDUCED IMMUNOGENICITY; STABILITY SHEARWATER CORPORATION 2002-02-19 US claimed
EP-0366041-B2 Imido-percarboxylic acids AUSIMONT SPA (IT) 2001-09-12 EP claimed
US-5817720-A GRAFT POLYMERS ENICHEM S.P.A. (IT) 1998-10-06 US claimed
EP-0366041-B1 Imido-percarboxylic acids AUSIMONT SPA (IT) 1998-08-05 EP claimed
EP-0792893-A2 Polyolefins modified with an unsaturated polyfunctional monomer containing an imide group and an ester group ENICHEM S.p.A. (IT) 1997-09-03 EP claimed
EP-0366041-A2 Imido-percarboxylic acids AUSIMONT S.r.l. (IT) 1990-05-02 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230090790-A1 LONG-ACTING CONJUGATES OF GLP-2 DERIVATIVES GIPR, VIP, GLP1R TSHR 528/4885KMT2A 2059/4885MEN1 969/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.