Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 7/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | CPA1 | P15085 | 1/20 | 0.31 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31631198 | 0.86 | MME (0.44) | ALDH1A1TDP1DPP4DPP9DPP8 | |
| SCHEMBL14985792 | 0.84 | SLC7A5 (0.48) | ALDH1A1SLC7A5 | |
| SCHEMBL25596628 | 0.84 | SLC7A5 (0.48) | ALDH1A1SLC7A5 | |
| SCHEMBL23901238 | 0.79 | ALDH1A1 (0.42) | ALDH1A1TDP1MMEACECPA1 | |
| SCHEMBL23748590 | 0.78 | DPP4 (0.44) | DPP4DPP9DPP8DPP7OPRD1 | |
| SCHEMBL23748421 | 0.76 | DPP4 (0.52) | DPP4DPP9DPP8DPP7SLC15A1 | |
| SCHEMBL13598645 | 0.76 | DPP4 (0.52) | DPP4DPP9DPP8DPP7SLC15A1 | |
| SCHEMBL121884 | 0.76 | DPP4 (0.52) | DPP4DPP9DPP8DPP7SLC15A1 | |
| SCHEMBL120711 | 0.74 | DPP7 (0.54) | DPP4DPP9DPP8DPP7SLC15A1 | |
| SCHEMBL14985783 | 0.74 | SLC7A5 (0.39) | ALDH1A1OPRD1OPRM1OPRK1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306125-B2 | PCSK9 antagonists bicyclo-compounds | MERCK SHARP & DOHME CORP. (US) | 2022-04-19 | — | — | US | disclosed |
| US-20210214395-A1 | PCSK9 ANTAGONISTS BICYCLO-COMPOUNDS | MERCK SHARP & DOHME LLC | 2021-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210214395-A1 | PCSK9 ANTAGONISTS BICYCLO-COMPOUNDS | PCSK9, PCSK7, PCSK6 | ALDH1A1 4478/4885TDP1 2293/4885DPP4 166/4885 |
| US-11306125-B2 | PCSK9 antagonists bicyclo-compounds | PCSK9, PCSK7, PCSK6 | ALDH1A1 4478/4885TDP1 2293/4885DPP4 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.