Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 1.00 |
| ▸ | TPH2 | Q8IWU9 | 11/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | CCKAR | P32238 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | MC3R | P41968 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308718 | 1.00 | TPH1 (1.00) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL29391423 | 1.00 | TPH1 (1.00) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL308719 | 1.00 | TPH1 (1.00) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL13878219 | 1.00 | TPH1 (1.00) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL870345 | 1.00 | TPH1 (1.00) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL870344 | 1.00 | TPH1 (1.00) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| Fumaric Acid SCHEMBL2927924 | 0.96 | TPH1 (0.93) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| Maleic Acid SCHEMBL2720175 | 0.96 | TPH1 (0.93) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| Fumaric Acid SCHEMBL2927928 | 0.96 | TPH1 (0.93) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL12128916 | 0.94 | TPH1 (0.89) | TPH1TPH2ADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113462728-B | Method for preparing (R) -1- (4-bromophenyl) -2, 2-trifluoroethanol by using starwheel head yeast | 浙江工业大学 | 2024-06-07 | — | — | CN | disclosed |
| CN-113462728-A | Method for preparing (R) -1- (4-bromophenyl) -2,2, 2-trifluoroethanol by using Verticillium terrestris | 浙江工业大学 | 2021-10-01 | — | — | CN | disclosed |
| EP-2358685-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | Lexicon Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| CN-101932563-A | Solid forms of (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and methods of their use | LEXICON PHARMACEUTICALS INC | 2010-12-29 | — | — | CN | disclosed |
| WO-2010047712-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | LEXICON PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |