Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 13/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24060234 | 0.92 | DHODH (0.52) | DHODHALDH1A1PARP1 | |
| SCHEMBL23645653 | 0.81 | DHODH (0.61) | DHODHPARP1 | |
| SCHEMBL23644566 | 0.80 | DHODH (0.50) | DHODH | |
| SCHEMBL21905269 | 0.76 | DHODH (1.00) | DHODH | |
| SCHEMBL17921461 | 0.76 | DHODH (0.67) | DHODHCYP2D6CYP2C9HIF1AHDAC6 | |
| SCHEMBL20482048 | 0.75 | DHODH (0.98) | DHODH | |
| SCHEMBL17921465 | 0.75 | DHODH (0.61) | DHODHCYP2D6CYP2C9HIF1AHDAC6 | |
| SCHEMBL25939563 | 0.75 | DHODH (0.61) | DHODHCYP2D6CYP2C9HIF1AHDAC6 | |
| SCHEMBL24060405 | 0.74 | DHODH (0.47) | DHODHCYP2D6CYP2C9HIF1AHDAC6 | |
| Trifluoroacetic Acid SCHEMBL26136007 | 0.73 | DHODH (0.92) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615027-B1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-07-14 | — | — | EP | disclosed |