Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30067506 | 0.89 | KRAS (0.44) | KRAS | |
| SCHEMBL30067614 | 0.88 | KRAS (0.38) | KRAS | |
| SCHEMBL23645279 | 0.88 | SIGMAR1 (0.34) | KRASSIGMAR1 | |
| SCHEMBL23645005 | 0.88 | SIGMAR1 (0.34) | KRASSIGMAR1 | |
| SCHEMBL23645007 | 0.88 | SIGMAR1 (0.34) | KRASSIGMAR1 | |
| SCHEMBL30067425 | 0.87 | KRAS (0.55) | KRAS | |
| SCHEMBL23668857 | 0.87 | KRAS (0.55) | KRAS | |
| SCHEMBL23644269 | 0.87 | KRAS (0.55) | KRAS | |
| SCHEMBL23644308 | 0.87 | KRAS (0.34) | KRAS | |
| SCHEMBL30067554 | 0.86 | KRAS (0.46) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021139748-A1 | SPIROCYCLIC TETRAHYDROQUINAZOLINES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-07-15 | — | — | WO | disclosed |