Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.60 |
| ▸ | JAK1 | P23458 | 20/20 | 0.60 |
| ▸ | JAK3 | P52333 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2234867 | 1.00 | JAK2 (0.60) | JAK2JAK1JAK3 | |
| SCHEMBL2232596 | 0.91 | JAK2 (0.56) | JAK2JAK1JAK3 | |
| SCHEMBL2232556 | 0.91 | JAK2 (0.59) | JAK2JAK1JAK3 | |
| SCHEMBL12346453 | 0.90 | JAK2 (0.54) | JAK2JAK1JAK3 | |
| SCHEMBL2344436 | 0.89 | JAK2 (0.75) | JAK2JAK1JAK3 | |
| SCHEMBL2235531 | 0.89 | JAK2 (0.54) | JAK2JAK1JAK3 | |
| SCHEMBL15167232 | 0.89 | JAK2 (0.75) | JAK2JAK1JAK3 | |
| SCHEMBL16669034 | 0.88 | JAK2 (0.51) | JAK2JAK1JAK3 | |
| SCHEMBL2233140 | 0.85 | JAK2 (0.61) | JAK2JAK1JAK3 | |
| SCHEMBL2301729 | 0.85 | JAK2 (0.61) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536728-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011101161-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |