Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21550500 | 1.00 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23646120 | 1.00 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23646118 | 1.00 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21550975 | 1.00 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21563277 | 0.93 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21563236 | 0.93 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23660785 | 0.93 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21563276 | 0.93 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7016175 | 0.93 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23058748 | 0.90 | SYK (0.50) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221823-A1 | TETRACYCLIC HETEROARYL COMPOUNDS | ASTRAZENECA AB (SE) | 2021-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221823-A1 | TETRACYCLIC HETEROARYL COMPOUNDS | CCNI, MCL1, MKI67 | KLK5 3453/4885PSEN1 1763/4885PSEN2 856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.