Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23039957 | 1.00 | SYK (0.50) | SYKPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15812057 | 1.00 | SYK (0.50) | SYKPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12606644 | 1.00 | SYK (0.50) | SYKPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23040048 | 0.92 | CTSK (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23059057 | 0.92 | CTSK (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23040049 | 0.92 | CTSK (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23042932 | 0.91 | PPARA (0.49) | SYKCTSSCTSKCTSLCTSB | |
| SCHEMBL23646147 | 0.90 | KLK5 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23646118 | 0.90 | KLK5 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23646120 | 0.90 | KLK5 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041588-A1 | SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-03-04 | — | — | WO | disclosed |