Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 10/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 10/20 | 0.43 |
| ▸ | BMX | P51813 | 9/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620382 | 0.84 | FGFR4 (0.61) | FGFR4TNK2MAP4K2BMXABL1 | |
| SCHEMBL1521938 | 0.80 | FGFR4 (0.56) | FGFR4TNK2MAP4K2BMXABL1 | |
| SCHEMBL6621872 | 0.79 | FGFR4 (0.62) | FGFR4TNK2MAP4K2BMXABL1 | |
| SCHEMBL1521396 | 0.76 | FGFR4 (0.52) | FGFR4TNK2MAP4K2BMXABL1 | |
| SCHEMBL6620598 | 0.76 | FGFR4 (0.71) | FGFR4TNK2MAP4K2ABL1FGFR1 | |
| SCHEMBL15412943 | 0.75 | FGFR4 (1.00) | FGFR4BMXFGFR1FGFR3KDR | |
| SCHEMBL5229018 | 0.73 | FGFR4 (0.61) | FGFR4LCKFGFR1FGFR3KDR | |
| SCHEMBL6618207 | 0.73 | FGFR4 (0.61) | FGFR4TNK2MAP4K2BMXABL1 | |
| SCHEMBL1521583 | 0.73 | FGFR4 (0.55) | FGFR4TNK2MAP4K2BMXABL1 | |
| SCHEMBL3573608 | 0.73 | FGFR4 (0.55) | FGFR4TNK2MAP4K2BMXABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021145520-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 한국과학기술연구원 | 2021-07-22 | — | — | WO | disclosed |
| WO-2021145520-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 한국과학기술연구원 | 2021-07-22 | — | — | WO | disclosed |