Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378422 | 0.91 | KDM4E (0.42) | KDM4EHSD17B10GAAMAPK1NAPEPLD | |
| SCHEMBL23665925 | 0.91 | NAPEPLD (0.46) | NAPEPLD | |
| SCHEMBL23665928 | 0.91 | KDM4E (0.49) | KDM4EHSD17B10GAAMAPK1NAPEPLD | |
| SCHEMBL26095931 | 0.90 | NAPEPLD (0.41) | KDM4EHSD17B10GAAMAPK1NAPEPLD | |
| SCHEMBL23665951 | 0.90 | KDM4E (0.41) | KDM4EHSD17B10GAAMAPK1NAPEPLD | |
| SCHEMBL23665913 | 0.89 | KDM4E (0.43) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL23665911 | 0.89 | KDM4E (0.43) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL23649022 | 0.88 | KDM4E (0.47) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL30042368 | 0.88 | KDM4E (0.47) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL26474829 | 0.88 | KDM4E (0.47) | KDM4EHSD17B10GAAMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115209952-B | Substituted pyrazolopyrimidines and use thereof | 维基分析有限公司 | 2025-05-30 | — | — | CN | claimed |
| EP-4090426-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2022-11-23 | — | — | EP | claimed |
| CN-115209952-A | Substituted pyrazolopyrimidines and use thereof | 维基分析有限公司 | 2022-10-18 | — | — | CN | claimed |
| WO-2021146192-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2021-07-22 | — | — | WO | claimed |
| US-12486274-B2 | Substituted pyrazolo-pyrimidines and uses thereof | Verge Analytics, Inc. (US) | 2025-12-02 | — | — | US | disclosed |
| CN-115209952-B | Substituted pyrazolopyrimidines and use thereof | 维基分析有限公司 | 2025-05-30 | — | — | CN | disclosed |
| US-20230133203-A1 | Substituted Pyrazolo-Pyrimidines and Uses Thereof | Verge Analytics, Inc. (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230133203-A1 | Substituted Pyrazolo-Pyrimidines and Uses Thereof | Verge Analytics, Inc. (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230133203-A1 | Substituted Pyrazolo-Pyrimidines and Uses Thereof | Verge Analytics, Inc. (US) | 2023-05-04 | — | — | US | disclosed |
| WO-2022261069-A1 | METHODS AND TREATMENT OF VIRAL INFECTION WITH SUBSTITUTED PYRAZOLO-PYRIMIDINES | Verge Analytics, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |
| EP-4090426-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2022-11-23 | — | — | EP | disclosed |
| CN-115209952-A | Substituted pyrazolopyrimidines and use thereof | 维基分析有限公司 | 2022-10-18 | — | — | CN | disclosed |
| WO-2021146192-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2021-07-22 | — | — | WO | disclosed |
| WO-2021146192-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2021-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133203-A1 | Substituted Pyrazolo-Pyrimidines and Uses Thereof | PIKFYVE, PIP4K2B, PIP4K2C | KDM4E 1122/4885HSD17B10 3596/4885GAA 792/4885 |
| US-12486274-B2 | Substituted pyrazolo-pyrimidines and uses thereof | PIKFYVE, PIP4K2B, PIP4K2C | KDM4E 1122/4885HSD17B10 3596/4885GAA 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.