Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13275627 | 0.83 | KDM5A (0.31) | KDM5ACYP2C9 | |
| SCHEMBL158835 | 0.80 | CYP2C9 (0.35) | KDM5ACYP2C9 | |
| SCHEMBL13465630 | 0.80 | FYN (0.45) | CYP2C9 | |
| SCHEMBL2222449 | 0.80 | NTRK1 (0.36) | KDM5APRMT5WDR77 | |
| SCHEMBL368935 | 0.80 | KDM5A (0.34) | KDM5APRMT5WDR77CYP2C9 | |
| SCHEMBL173996 | 0.79 | CYP2C9 (0.37) | KDM5ACYP2C9 | |
| SCHEMBL2274025 | 0.79 | ENPP2 (0.34) | CYP2C9 | |
| SCHEMBL13275402 | 0.79 | CYP2C9 (0.30) | CYP2C9 | |
| SCHEMBL2223676 | 0.79 | ENPP2 (0.42) | CYP2C9 | |
| SCHEMBL173258 | 0.79 | PARP1 (0.38) | AURKBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |