Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.74 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16072330 | 0.90 | FGFR4 (0.71) | FGFR4LCKMAPK14FGFR1SIK2 | |
| SCHEMBL21860438 | 0.89 | FGFR4 (0.81) | FGFR4LCKMAPK14FGFR1TNK2 | |
| SCHEMBL6622549 | 0.87 | LCK (0.69) | FGFR4LCKMAPK14FGFR1SIK2 | |
| SCHEMBL16071751 | 0.85 | FGFR4 (1.00) | FGFR4LCKMAPK14FGFR1FGFR2 | |
| SCHEMBL6620907 | 0.82 | LCK (0.68) | FGFR4LCKMAPK14FGFR1SIK2 | |
| SCHEMBL23653237 | 0.81 | FGFR4 (0.91) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL6618406 | 0.81 | FGFR4 (0.60) | FGFR4LCKMAPK14FGFR1SIK2 | |
| SCHEMBL6619138 | 0.80 | LCK (0.74) | FGFR4LCKMAPK14FGFR1SIK2 | |
| SCHEMBL6620252 | 0.80 | MAPK14 (0.66) | FGFR4LCKMAPK14FGFR1SIK2 | |
| SCHEMBL6619141 | 0.78 | FGFR4 (0.57) | FGFR4LCKMAPK14FGFR1TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968337-B1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2021-07-21 | — | — | EP | disclosed |