Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 9/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619414 | 0.93 | FGFR4 (0.53) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL6618406 | 0.91 | FGFR4 (0.60) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL6622200 | 0.83 | FGFR4 (0.56) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL6622549 | 0.83 | LCK (0.69) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL6620252 | 0.80 | MAPK14 (0.66) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL6621690 | 0.80 | FGFR4 (0.54) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL3968454 | 0.79 | LCK (0.61) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL3970897 | 0.79 | MAPK14 (0.61) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL23653236 | 0.78 | FGFR4 (0.74) | FGFR4MAPK14LCKTNK2MAP4K2 | |
| SCHEMBL16072330 | 0.78 | FGFR4 (0.71) | FGFR4MAPK14LCKTNK2MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123295-B1 | BICYCLIC NITROGEN HETEROCYCLES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| EP-1123295-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| US-6150373-A | AMINO-SUBSTITUTED DIHYDROPYRIMIDO(4,5-D)PYRIMIDINONE DERIVATIVES; INHIBITORS OF THE T-CELL TYROSINE KINASE P56LCK; IMMUNOSUPPRESSANTS; ANTIINFLAMMATORY/-CARCINOGENIC AGENTS; BRONCHOPULMONARY, DERMATOLOGICAL AND CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-2000024744-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | disclosed |