SCHEMBL23653630

CC(C)N(C)c1c(F)cc([C@H]2C[C@@]3(C)[C@@H](CC[C@@]3(O)C#CC(C)(C)CC3CCN(c4ccc([C@H]5C[C@@]6(C)[C@@H](CC[C@@]6(O)C#CC(C)(C)C)[C@@H]6CCC7=CC(=O)CC[C@]7(C)[C@H]65)cc4)C3)[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]32)cc1F

nearest known ligand 0.58

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1	P04150	20/20	0.58

▸	PGR	P06401	19/20	0.58

▸	AR	P10275	16/20	0.58

▸	CYP3A4	P08684	1/20	0.58

▸	CYP2C8	P10632	1/20	0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20048249	0.82	NR3C1 (0.77)	NR3C1PGRARCYP3A4
SCHEMBL20048340	0.77	NR3C1 (0.79)	NR3C1PGRARCYP3A4
SCHEMBL20048342	0.76	NR3C1 (0.85)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL20048406	0.75	NR3C1 (0.84)	NR3C1PGRARCYP2C8
SCHEMBL20048238	0.75	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL21143406	0.75	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL20048236	0.75	NR3C1 (0.88)	NR3C1PGRARCYP3A4
SCHEMBL20048341	0.73	NR3C1 (1.00)	NR3C1PGRARCYP3A4
SCHEMBL20048086	0.73	NR3C1 (1.00)	NR3C1PGRARCYP3A4
SCHEMBL21729672	0.72	NR3C1 (0.71)	NR3C1PGRARCYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3851444-A1	INHIBITORS OF GLUCOCORTICOID RECEPTOR	Oric Pharmaceuticals, Inc. (US)	2021-07-21	—	—	EP	disclosed