Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 5/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | CA7 | P43166 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548930 | 0.97 | NR3C2 (0.85) | NR3C2ALDH1A1LMNAPOLBCA1 | |
| SCHEMBL2548305 | 0.97 | NR3C2 (0.75) | NR3C2ALDH1A1LMNAPOLBCA1 | |
| SCHEMBL2365487 | 0.91 | NR3C2 (0.67) | NR3C2ALDH1A1CA1CA2CA9 | |
| SCHEMBL2357173 | 0.90 | NR3C2 (1.00) | NR3C2LMNAPOLBTMPRSS4 | |
| SCHEMBL2365402 | 0.89 | NR3C2 (0.65) | NR3C2ALDH1A1LMNAPOLBCA1 | |
| SCHEMBL2545125 | 0.88 | NR3C2 (0.70) | NR3C2ALDH1A1CA1CA2CA9 | |
| SCHEMBL2548973 | 0.87 | NR3C2 (0.61) | NR3C2ALDH1A1CA1CA2CA9 | |
| SCHEMBL2359038 | 0.80 | NR3C2 (0.82) | NR3C2 | |
| SCHEMBL2365488 | 0.80 | NR3C2 (0.54) | NR3C2CA1CA2CA9CA7 | |
| SCHEMBL2357087 | 0.80 | NR3C2 (0.81) | NR3C2LMNAPOLBTMPRSS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349996-A1 | 1-PHENYLPYRROLE COMPOUNDS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010042626-A1 | 1-PHENYLPYRROLE COMPOUNDS | EXELIXIS, INC. (US) | 2010-04-15 | — | — | WO | disclosed |