Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.64 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.63 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.63 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.63 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.63 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.63 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.63 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.63 |
| ▸ | AKT1 | P31749 | 11/20 | 0.63 |
| ▸ | AKT2 | P31751 | 4/20 | 0.63 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14782536 | 0.80 | RPS6KB1 (0.62) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL311253 | 0.79 | RPS6KB1 (0.61) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732549 | 0.79 | RPS6KB1 (0.61) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Ly-2584702 SCHEMBL311369 | 0.78 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL3726131 | 0.78 | RPS6KB1 (0.77) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Ly-2584702 SCHEMBL29493101 | 0.78 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Ly-2584702 SCHEMBL312564 | 0.78 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL14782708 | 0.78 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL14782531 | 0.77 | RPS6KB1 (1.00) | RPS6KB1AKT1AKT2AKT3KCNH2 | |
| SCHEMBL14786368 | 0.77 | RPS6KB1 (1.00) | RPS6KB1AKT1AKT2AKT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056574-A1 | P70 S6 KINASE INHIBITOR AND MTOR INHIBITOR COMBINATION THERAPY | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | claimed |
| WO-2010056575-A1 | P70 S6 KINASE INHIBITOR AND EGFR INHIBITOR COMBINATION THERAPY | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | claimed |
| WO-2016040078-A1 | SUBSTITUTED PHENYL IMIDAZOLYL PIPERIDYL COMPOUNDS AS P70S6K1 INHIBITORS | ELI LILLY AND COMPANY (US) | 2016-03-17 | — | — | WO | disclosed |
| EP-2355820-A1 | P70 S6 KINASE INHIBITOR AND MTOR INHIBITOR COMBINATION THERAPY | Eli Lilly and Company (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010056574-A1 | P70 S6 KINASE INHIBITOR AND MTOR INHIBITOR COMBINATION THERAPY | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056575-A1 | P70 S6 KINASE INHIBITOR AND EGFR INHIBITOR COMBINATION THERAPY | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |
| EP-2148880-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008140947-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2008-11-20 | — | — | WO | disclosed |